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ENDOTHELIAL CELL TOLERANCE TO LIPOPOLYSACCHARIDE CHALLENGE IS INDUCED BY MONOPHOSPHORYL LIPID A
Prior exposure to lipopolysaccharide (LPS) produces a reduced or “tolerant” inflammatory response to subsequent challenges with LPS, however the potent pro-inflammatory effects of LPS limit its clinical benefit. The adjuvant Monophosphoryl lipid A (MPLA) is a weak toll-like receptor 4 (TLR4) agonist...
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Publicado no: | Clin Sci (Lond) |
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Main Authors: | , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4744094/ https://ncbi.nlm.nih.gov/pubmed/26669797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20150592 |
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