Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei

OBJECTIVES: The objective of this study was to identify the mechanisms of resistance to nifurtimox and fexinidazole in African trypanosomes. METHODS: Bloodstream-form Trypanosoma brucei were selected for resistance to nifurtimox and fexinidazole by stepwise exposure to increasing drug concentrations...

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Detalles Bibliográficos
Publicado en:J Antimicrob Chemother
Autores principales: Wyllie, Susan, Foth, Bernardo J., Kelner, Anna, Sokolova, Antoaneta Y., Berriman, Matthew, Fairlamb, Alan H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743696/
https://ncbi.nlm.nih.gov/pubmed/26581221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv376
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