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Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei
OBJECTIVES: The objective of this study was to identify the mechanisms of resistance to nifurtimox and fexinidazole in African trypanosomes. METHODS: Bloodstream-form Trypanosoma brucei were selected for resistance to nifurtimox and fexinidazole by stepwise exposure to increasing drug concentrations...
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| Publicado no: | J Antimicrob Chemother |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4743696/ https://ncbi.nlm.nih.gov/pubmed/26581221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv376 |
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