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Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania
Drug discovery pipelines for the “neglected diseases” are now heavily populated with nitroheterocyclic compounds. Recently, the bicyclic nitro-compounds (R)-PA-824, DNDI-VL-2098 and delamanid have been identified as potential candidates for the treatment of visceral leishmaniasis. Using a combinatio...
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| Gepubliceerd in: | PLoS Pathog |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5094698/ https://ncbi.nlm.nih.gov/pubmed/27812217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005971 |
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