Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania

Drug discovery pipelines for the “neglected diseases” are now heavily populated with nitroheterocyclic compounds. Recently, the bicyclic nitro-compounds (R)-PA-824, DNDI-VL-2098 and delamanid have been identified as potential candidates for the treatment of visceral leishmaniasis. Using a combinatio...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Wyllie, Susan, Roberts, Adam J., Norval, Suzanne, Patterson, Stephen, Foth, Bernardo J., Berriman, Matthew, Read, Kevin D., Fairlamb, Alan H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094698/
https://ncbi.nlm.nih.gov/pubmed/27812217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005971
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