The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei

Messenger RNA is modified by the addition of a 5′ methylated cap structure, which protects the transcript and recruits protein complexes that mediate RNA processing and/or the initiation of translation. Two genes encoding mRNA cap methyltransferases have been identified in T. brucei: TbCMT1 and TbCG...

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Publicado en:PLoS One
Autores principales: Kelner, Anna, Tinti, Michele, Guther, Maria Lucia S., Foth, Bernardo J., Chappell, Lia, Berriman, Matthew, Cowling, Victoria Haigh, Ferguson, Michael A. J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057678/
https://ncbi.nlm.nih.gov/pubmed/30040830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201263
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