BK channel β1-subunit deficiency exacerbates vascular fibrosis and remodeling but does not promote hypertension in high fat fed obesity in mice

OBJECTIVE: Reduced expression or increased degradation of BK (large conductance Ca(2+)-activated K(+)) channel β1-subunits has been associated with increased vascular tone and hypertension in some metabolic diseases. The contribution of BK channel function to control of blood pressure (BP), heart ra...

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Bibliographic Details
Published in:J Hypertens
Main Authors: Xu, Hui, Garver, Hannah, Fernandes, Roxanne, Phelps, Jeremiah T, Harkema, Jack J, Galligan, James J, Fink, Gregory D
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743538/
https://ncbi.nlm.nih.gov/pubmed/26049174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HJH.0000000000000590
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