Altered L-type Ca(2+) channel activity contributes to exacerbated hypoperfusion and mortality in smooth muscle cell BK channel-deficient septic mice

We determined the contribution of vascular large conductance Ca(2+)-activated K(+) (BK) and L-type Ca(2+) channel dysregulation to exaggerated mortality in cecal ligation/puncture (CLP)-induced septic BK channel β1-subunit knockout (BK β1-KO, smooth muscle specific) mice. CLP-induced hemodynamic cha...

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Detalhes bibliográficos
Main Authors: Xu, Hui, Garver, Hannah, Fernandes, Roxanne, Galligan, James J., Fink, Gregory D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Cardiovascular and Renal Integration
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101616/
https://ncbi.nlm.nih.gov/pubmed/24829499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00117.2014
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