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Vascular BK channel deficiency exacerbates organ damage and mortality in endotoxemic mice

We determined the contribution of vascular BK channels to endotoxin (lipopolysaccharide, LPS)-induced hypotension, organ damage, and mortality using smooth muscle BK channel deficiency (BK channel β1-subunit knockout, BK β1-KO) mice. BK β1-KO mice were more sensitive to LPS-induced mortality compare...

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書目詳細資料
發表在:J Cardiovasc Pharmacol
Main Authors: Xu, Hui, Wang, Youping, Garver, Hannah, Galligan, James J., Fink, Gregory D.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4327844/
https://ncbi.nlm.nih.gov/pubmed/21997262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0b013e31823b493b
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