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Structural basis of complement membrane attack complex formation
In response to complement activation, the membrane attack complex (MAC) assembles from fluid-phase proteins to form pores in lipid bilayers. MAC directly lyses pathogens by a ‘multi-hit' mechanism; however, sublytic MAC pores on host cells activate signalling pathways. Previous studies have des...
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| Gepubliceerd in: | Nat Commun |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4743022/ https://ncbi.nlm.nih.gov/pubmed/26841837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10587 |
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