Specific Inter-residue Interactions as Determinants of Human Monoacylglycerol Lipase Catalytic Competency: A ROLE FOR GLOBAL CONFORMATIONAL CHANGES

The serine hydrolase monoacylglycerol lipase (MGL) functions as the main metabolizing enzyme of 2-arachidonoyl glycerol, an endocannabinoid signaling lipid whose elevation through genetic or pharmacological MGL ablation exerts therapeutic effects in various preclinical disease models. To inform stru...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Tyukhtenko, Sergiy, Karageorgos, Ioannis, Rajarshi, Girija, Zvonok, Nikolai, Pavlopoulos, Spiro, Janero, David R., Makriyannis, Alexandros
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742725/
https://ncbi.nlm.nih.gov/pubmed/26555264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.670257
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