Effects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase

An understanding of how conformational dynamics modulates function and catalysis of human monoacylglycerol lipase (hMGL), an important pharmaceutical target, can facilitate the development of novel ligands with potential therapeutic value. Here, we report the discovery and characterization of an all...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tyukhtenko, Sergiy, Rajarshi, Girija, Karageorgos, Ioannis, Zvonok, Nikolai, Gallagher, Elyssia S., Huang, Hongwei, Vemuri, Kiran, Hudgens, Jeffrey W., Ma, Xiaoyu, Nasr, Mahmoud L., Pavlopoulos, Spiro, Makriyannis, Alexandros
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789057/
https://ncbi.nlm.nih.gov/pubmed/29379013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-19135-7
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