Effects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase

An understanding of how conformational dynamics modulates function and catalysis of human monoacylglycerol lipase (hMGL), an important pharmaceutical target, can facilitate the development of novel ligands with potential therapeutic value. Here, we report the discovery and characterization of an all...

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Publicado en:Sci Rep
Main Authors: Tyukhtenko, Sergiy, Rajarshi, Girija, Karageorgos, Ioannis, Zvonok, Nikolai, Gallagher, Elyssia S., Huang, Hongwei, Vemuri, Kiran, Hudgens, Jeffrey W., Ma, Xiaoyu, Nasr, Mahmoud L., Pavlopoulos, Spiro, Makriyannis, Alexandros
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789057/
https://ncbi.nlm.nih.gov/pubmed/29379013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-19135-7
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