Covalent Inhibitors of Human Monoacylglycerol Lipase: Ligand-assisted Characterization of the Catalytic Site by Mass Spectrometry and Mutational Analysis

The serine esterase monoacylglycerol lipase (MGL) is primarily responsible for deactivating the signaling lipid 2-arachidonoylglycerol (2-AG), an endocannabinoid with full agonist activity at both principal cannabinoid receptors. Although MGL is recognized as a potential therapeutic target, the pauc...

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Autors principals: Zvonok, Nikolai, Pandarinathan, Lakshmipathi, Williams, John, Johnston, Meghan, Karageorgos, Ioannis, Janero, David R., Krishnan, Srinivasan C., Makriyannis, Alexandros
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972761/
https://ncbi.nlm.nih.gov/pubmed/18721756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.06.008
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