Full Mass Spectrometric Characterization of Human Monoacylglycerol Lipase Generated by Large-Scale Expression and Single-Step Purification

The serine hydrolase monoacylglycerol lipase (MGL) modulates endocannabinoid signaling in vivo by inactivating 2-arachidonoylglycerol (2-AG), the main endogenous agonist for central CB1 and peripheral CB2 cannabinoid receptors. To characterize this key endocannabinoid enzyme by mass spectrometry-bas...

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Autori principali: Zvonok, Nikolai, Williams, John, Johnston, Meghan, Pandarinathan, Lakshmipathi, Janero, David R., Li, Jing, Krishnan, Srinivasan C., Makriyannis, Alexandros
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689545/
https://ncbi.nlm.nih.gov/pubmed/18452279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr700839z
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