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The NADase-Negative Variant of the Streptococcus pyogenes Toxin NAD(+) Glycohydrolase Induces JNK1-Mediated Programmed Cellular Necrosis
Virulence factors are often multifunctional and contribute to pathogenesis through synergistic mechanisms. For the human pathogen Streptococcus pyogenes, two factors that act synergistically are the S. pyogenes NAD(+) glycohydrolase (SPN) and streptolysin O (SLO). Through distinct mechanisms, SLO fo...
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| Publicado no: | mBio |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Microbiology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4742715/ https://ncbi.nlm.nih.gov/pubmed/26838722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02215-15 |
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