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The Streptococcus pyogenes NAD(+) Glycohydrolase Modulates Epithelial Cell PARylation and HMGB1 Release

Streptococcus pyogenes uses the cytolysin Streptolysin O (SLO) to translocate an enzyme, the S. pyogenes NAD(+) glycohydrolase (SPN), into the host cell cytosol. However, the function of SPN in this compartment is not known. As a complication, many S. pyogenes strains express a SPN variant lacking N...

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Publicado en:Cell Microbiol
Main Authors: Chandrasekaran, Sukantha, Caparon, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624300/
https://ncbi.nlm.nih.gov/pubmed/25818652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cmi.12442
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