Analysis of Polymorphic Residues Reveals Distinct Enzymatic and Cytotoxic Activities of the Streptococcus pyogenes NAD(+) Glycohydrolase

The Streptococcus pyogenes NAD(+) glycohydrolase (SPN) is secreted from the bacterial cell and translocated into the host cell cytosol where it contributes to cell death. Recent studies suggest that SPN is evolving and has diverged into NAD(+) glycohydrolase-inactive variants that correlate with tis...

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Bibliografiska uppgifter
Huvudupphovsmän: Chandrasekaran, Sukantha, Ghosh, Joydeep, Port, Gary C., Koh, Eun-ik, Caparon, Michael G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2013
Ämnen:
Enzymology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707703/
https://ncbi.nlm.nih.gov/pubmed/23689507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.481556
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