Analysis of Polymorphic Residues Reveals Distinct Enzymatic and Cytotoxic Activities of the Streptococcus pyogenes NAD(+) Glycohydrolase

The Streptococcus pyogenes NAD(+) glycohydrolase (SPN) is secreted from the bacterial cell and translocated into the host cell cytosol where it contributes to cell death. Recent studies suggest that SPN is evolving and has diverged into NAD(+) glycohydrolase-inactive variants that correlate with tis...

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Hauptverfasser: Chandrasekaran, Sukantha, Ghosh, Joydeep, Port, Gary C., Koh, Eun-ik, Caparon, Michael G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707703/
https://ncbi.nlm.nih.gov/pubmed/23689507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.481556
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