Analysis of Polymorphic Residues Reveals Distinct Enzymatic and Cytotoxic Activities of the Streptococcus pyogenes NAD(+) Glycohydrolase

The Streptococcus pyogenes NAD(+) glycohydrolase (SPN) is secreted from the bacterial cell and translocated into the host cell cytosol where it contributes to cell death. Recent studies suggest that SPN is evolving and has diverged into NAD(+) glycohydrolase-inactive variants that correlate with tis...

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Hlavní autoři: Chandrasekaran, Sukantha, Ghosh, Joydeep, Port, Gary C., Koh, Eun-ik, Caparon, Michael G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707703/
https://ncbi.nlm.nih.gov/pubmed/23689507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.481556
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