PRMT6 increases cytoplasmic localization of p21(CDKN1A) in cancer cells through arginine methylation and makes more resistant to cytotoxic agents

p21(CDKN1A) is known as a potent inhibitor of cyclin-dependent kinase (CDK), which regulates cell cycle in response to various stimuli, including DNA damage, on the p53-dependent manner. Here we demonstrate that protein arginine methyltransferase 6 (PRMT6) methylates p21 at arginine 156 and promotes...

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Publicat a:Oncotarget
Autors principals: Nakakido, Makoto, Deng, Zhenzhong, Suzuki, Takehiro, Dohmae, Naoshi, Nakamura, Yusuke, Hamamoto, Ryuji
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741580/
https://ncbi.nlm.nih.gov/pubmed/26436589
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