SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1

AKT1 is a cytosolic serine/threonine kinase that is overexpressed in various types of cancer and has a central role in human tumorigenesis. Although it is known that AKT1 is post-translationally modified in various ways including phosphorylation and ubiquitination, methylation has not been reported...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yoshioka, Yuichiro, Suzuki, Takehiro, Matsuo, Yo, Nakakido, Makoto, Tsurita, Giichiro, Simone, Cristiano, Watanabe, Toshiaki, Dohmae, Naoshi, Nakamura, Yusuke, Hamamoto, Ryuji
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342720/
https://ncbi.nlm.nih.gov/pubmed/27626683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11898
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