SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1

AKT1 is a cytosolic serine/threonine kinase that is overexpressed in various types of cancer and has a central role in human tumorigenesis. Although it is known that AKT1 is post-translationally modified in various ways including phosphorylation and ubiquitination, methylation has not been reported...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Oncotarget
Κύριοι συγγραφείς: Yoshioka, Yuichiro, Suzuki, Takehiro, Matsuo, Yo, Nakakido, Makoto, Tsurita, Giichiro, Simone, Cristiano, Watanabe, Toshiaki, Dohmae, Naoshi, Nakamura, Yusuke, Hamamoto, Ryuji
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Impact Journals LLC 2016
Θέματα:
Research Paper
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342720/
https://ncbi.nlm.nih.gov/pubmed/27626683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11898
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