Critical roles of SMYD2-mediated β-catenin methylation for nuclear translocation and activation of Wnt signaling

Accumulation of β-catenin in the nucleus is a hallmark of activation of the Wnt/β-catenin signaling pathway, which drives development of a large proportion of human cancers. However, the mechanism of β-catenin nuclear translocation has not been well investigated. Here we report biological significan...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Deng, Xiaolan, Hamamoto, Ryuji, Vougiouklakis, Theodore, Wang, Rui, Yoshioka, Yuichiro, Suzuki, Takehiro, Dohmae, Naoshi, Matsuo, Yo, Park, Jae-Hyun, Nakamura, Yusuke
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593527/
https://ncbi.nlm.nih.gov/pubmed/28915556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19646
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