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Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN()()
Phosphatase and tensin homologue (PTEN), one of the well-characterized tumor suppressor proteins, counteracts the phosphatidylinositol 3-kinase-AKT pathway through its unique lipid phosphatase activity. The functions of PTEN are regulated by a variety of posttranslational modifications such as acety...
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| Udgivet i: | Neoplasia |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Neoplasia Press
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4415136/ https://ncbi.nlm.nih.gov/pubmed/25925379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2015.03.002 |
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