Automethylation of SUV39H2, an oncogenic histone lysine methyltransferase, regulates its binding affinity to substrate proteins

We previously reported that the histone lysine methyltransferase SUV39H2, which is overexpressed in various types of human cancer, plays a critical role in the DNA repair after double strand breakage, and possesses oncogenic activity. Although its biological significance in tumorigenesis has been el...

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Опубликовано в: :Oncotarget
Главные авторы: Piao, Lianhua, Nakakido, Makoto, Suzuki, Takehiro, Dohmae, Naoshi, Nakamura, Yusuke, Hamamoto, Ryuji
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2016
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008405/
https://ncbi.nlm.nih.gov/pubmed/26988914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8072
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