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Automethylation of SUV39H2, an oncogenic histone lysine methyltransferase, regulates its binding affinity to substrate proteins

We previously reported that the histone lysine methyltransferase SUV39H2, which is overexpressed in various types of human cancer, plays a critical role in the DNA repair after double strand breakage, and possesses oncogenic activity. Although its biological significance in tumorigenesis has been el...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Piao, Lianhua, Nakakido, Makoto, Suzuki, Takehiro, Dohmae, Naoshi, Nakamura, Yusuke, Hamamoto, Ryuji
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008405/
https://ncbi.nlm.nih.gov/pubmed/26988914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8072
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