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SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells
LSD1 is a histone lysine demethylase, which is highly expressed in multiple types of human cancer. Although its roles in transcriptional regulation have been well-studied, functional regulation of LSD1 by post-translational modifications still remains unknown. Here, we demonstrate that the histone l...
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| Publicado no: | Oncotarget |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4627283/ https://ncbi.nlm.nih.gov/pubmed/26183527 |
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