Targeted Gene Transfer to the Brain via the Delivery of Brain-Penetrating DNA Nanoparticles with Focused Ultrasound

Gene therapy holds promise for the treatment of many pathologies of the central nervous system (CNS), including brain tumors and neurodegenerative diseases. However, the delivery of systemically administered gene carriers to the CNS is hindered by both the blood-brain barrier (BBB) and the nanoporou...

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Veröffentlicht in:J Control Release
Hauptverfasser: Mead, Brian P., Mastorakos, Panagiotis, Suk, Jung Soo, Klibanov, Alexander L., Hanes, Justin, Price, Richard J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739627/
https://ncbi.nlm.nih.gov/pubmed/26732553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2015.12.034
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