MR Image-Guided Delivery of Cisplatin-Loaded Brain-Penetrating Nanoparticles to Invasive Glioma with Focused Ultrasound

Systemically administered chemotherapeutic drugs are often ineffective in the treatment of invasive brain tumors due to poor therapeutic index. Within gliomas, despite the presence of heterogeneously leaky microvessels, dense extracellular matrix and high interstitial pressure generate a “blood-tumo...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Timbie, Kelsie F, Afzal, Umara, Date, Abhijit, Zhang, Clark, Song, Ji, Miller, G. Wilson, Suk, Jung Soo, Hanes, Justin, Price, Richard J
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593770/
https://ncbi.nlm.nih.gov/pubmed/28288892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2017.03.017
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