MR Image-Guided Delivery of Cisplatin-Loaded Brain-Penetrating Nanoparticles to Invasive Glioma with Focused Ultrasound

Systemically administered chemotherapeutic drugs are often ineffective in the treatment of invasive brain tumors due to poor therapeutic index. Within gliomas, despite the presence of heterogeneously leaky microvessels, dense extracellular matrix and high interstitial pressure generate a “blood-tumo...

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Vydáno v:J Control Release
Hlavní autoři: Timbie, Kelsie F, Afzal, Umara, Date, Abhijit, Zhang, Clark, Song, Ji, Miller, G. Wilson, Suk, Jung Soo, Hanes, Justin, Price, Richard J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593770/
https://ncbi.nlm.nih.gov/pubmed/28288892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2017.03.017
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