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MR Image-Guided Delivery of Cisplatin-Loaded Brain-Penetrating Nanoparticles to Invasive Glioma with Focused Ultrasound

Systemically administered chemotherapeutic drugs are often ineffective in the treatment of invasive brain tumors due to poor therapeutic index. Within gliomas, despite the presence of heterogeneously leaky microvessels, dense extracellular matrix and high interstitial pressure generate a “blood-tumo...

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Detalles Bibliográficos
Publicado en:J Control Release
Autores principales: Timbie, Kelsie F, Afzal, Umara, Date, Abhijit, Zhang, Clark, Song, Ji, Miller, G. Wilson, Suk, Jung Soo, Hanes, Justin, Price, Richard J
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593770/
https://ncbi.nlm.nih.gov/pubmed/28288892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2017.03.017
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