Augmentation of brain tumor interstitial flow via focused ultrasound promotes brain-penetrating nanoparticle dispersion and transfection

The delivery of systemically administered gene therapies to brain tumors is exceptionally difficult because of the blood-brain barrier (BBB) and blood-tumor barrier (BTB). In addition, the adhesive and nanoporous tumor extracellular matrix hinders therapeutic dispersion. We first developed the use o...

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Pubblicato in:Sci Adv
Autori principali: Curley, Colleen T., Mead, Brian P., Negron, Karina, Kim, Namho, Garrison, William J., Miller, G. Wilson, Kingsmore, Kathryn M., Thim, E. Andrew, Song, Ji, Munson, Jennifer M., Klibanov, Alexander L., Suk, Jung Soo, Hanes, Justin, Price, Richard J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195188/
https://ncbi.nlm.nih.gov/pubmed/32494662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay1344
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