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Sonoselective transfection of cerebral vasculature without blood–brain barrier disruption

Treatment of many pathologies of the brain could be improved markedly by the development of noninvasive therapeutic approaches that elicit robust, endothelial cell-selective gene expression in specific brain regions that are targeted under MR image guidance. While focused ultrasound (FUS) in conjunc...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Gorick, Catherine M., Mathew, Alexander S., Garrison, William J., Thim, E. Andrew, Fisher, Delaney G., Copeland, Caitleen A., Song, Ji, Klibanov, Alexander L., Miller, G. Wilson, Price, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084076/
https://ncbi.nlm.nih.gov/pubmed/32123081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914595117
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