Inhibition of mutant Kras(G12D)–initiated murine pancreatic carcinoma growth by a dual c-Raf and soluble epoxide hydrolase inhibitor t-CUPM

Mutant Kras and chronic pancreatitis are the most common pathologic events involved in human pancreatic cancer. It has been demonstrated that c-Raf is responsible for transmitting signals from mutant Ras to its downstream signals including MEK-ERK and for initiating carcinogenesis. The soluble epoxi...

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Vydáno v:Cancer Lett
Hlavní autoři: Liao, Jie, Hwang, Sung Hee, Li, Haonan, Yang, Yihe, Yang, Jun, Wecksler, Aaron T., Liu, Jun-Yan, Hammock, Bruce D., Yang, Guang-Yu
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738175/
https://ncbi.nlm.nih.gov/pubmed/26683769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.11.042
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