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Inhibition of mutant Kras(G12D)–initiated murine pancreatic carcinoma growth by a dual c-Raf and soluble epoxide hydrolase inhibitor t-CUPM
Mutant Kras and chronic pancreatitis are the most common pathologic events involved in human pancreatic cancer. It has been demonstrated that c-Raf is responsible for transmitting signals from mutant Ras to its downstream signals including MEK-ERK and for initiating carcinogenesis. The soluble epoxi...
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| Veröffentlicht in: | Cancer Lett |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4738175/ https://ncbi.nlm.nih.gov/pubmed/26683769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.11.042 |
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