Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Self-renewing tissue-resident macrophages are thought to be exclusively derived from embryonic progenitors. However, whether circulating monocytes can also give rise to such macrophages has not been formally investigated. Here we use a new model of diphtheria toxin-mediated depletion of liver-reside...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Scott, Charlotte L., Zheng, Fang, De Baetselier, Patrick, Martens, Liesbet, Saeys, Yvan, De Prijck, Sofie, Lippens, Saskia, Abels, Chloé, Schoonooghe, Steve, Raes, Geert, Devoogdt, Nick, Lambrecht, Bart N., Beschin, Alain, Guilliams, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737801/
https://ncbi.nlm.nih.gov/pubmed/26813785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10321
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