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Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Self-renewing tissue-resident macrophages are thought to be exclusively derived from embryonic progenitors. However, whether circulating monocytes can also give rise to such macrophages has not been formally investigated. Here we use a new model of diphtheria toxin-mediated depletion of liver-reside...

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Publicado en:Nat Commun
Autores principales: Scott, Charlotte L., Zheng, Fang, De Baetselier, Patrick, Martens, Liesbet, Saeys, Yvan, De Prijck, Sofie, Lippens, Saskia, Abels, Chloé, Schoonooghe, Steve, Raes, Geert, Devoogdt, Nick, Lambrecht, Bart N., Beschin, Alain, Guilliams, Martin
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737801/
https://ncbi.nlm.nih.gov/pubmed/26813785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10321
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