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New furin inhibitors based on weakly basic amidinohydrazones
A novel series of amidinohydrazone-derived furin inhibitors was prepared, the most potent compounds 17 and 21 inhibit furin with K(i) values of 0.46 and 0.59 µM, respectively. In contrast to inhibitor 17, which still contains a guanidino residue, compound 21 possesses only weakly basic amidinohydraz...
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| Veröffentlicht in: | Bioorg Med Chem Lett |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4737580/ https://ncbi.nlm.nih.gov/pubmed/21168329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.11.092 |
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