Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor

Pyruvate kinase M2 (PKM2) and pyruvate dehydrogenase complex (PDC) regulate production of acetyl-CoA, which functions as an acetyl donor in diverse enzymatic reactions, including histone acetylation. However, the mechanism by which the acetyl-CoA required for histone acetylation is ensured in a gene...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Matsuda, Shun, Adachi, Jun, Ihara, Masaru, Tanuma, Nobuhiro, Shima, Hiroshi, Kakizuka, Akira, Ikura, Masae, Ikura, Tsuyoshi, Matsuda, Tomonari
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737187/
https://ncbi.nlm.nih.gov/pubmed/26405201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv967
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