Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome

Mutations of the Glu76 residue of canonical histone H2B are frequently found in cancer cells. However, it is quite mysterious how a single amino acid substitution in one of the multiple H2B genes affects cell fate. Here we found that the H2B E76K mutation, in which Glu76 is replaced by Lys (E76K), d...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Arimura, Yasuhiro, Ikura, Masae, Fujita, Risa, Noda, Mamiko, Kobayashi, Wataru, Horikoshi, Naoki, Sun, Jiying, Shi, Lin, Kusakabe, Masayuki, Harata, Masahiko, Ohkawa, Yasuyuki, Tashiro, Satoshi, Kimura, Hiroshi, Ikura, Tsuyoshi, Kurumizaka, Hitoshi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2018
Onderwerpen:
Gene regulation, Chromatin and Epigenetics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212774/
https://ncbi.nlm.nih.gov/pubmed/30053102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky661
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