Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome

Mutations of the Glu76 residue of canonical histone H2B are frequently found in cancer cells. However, it is quite mysterious how a single amino acid substitution in one of the multiple H2B genes affects cell fate. Here we found that the H2B E76K mutation, in which Glu76 is replaced by Lys (E76K), d...

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Arimura, Yasuhiro, Ikura, Masae, Fujita, Risa, Noda, Mamiko, Kobayashi, Wataru, Horikoshi, Naoki, Sun, Jiying, Shi, Lin, Kusakabe, Masayuki, Harata, Masahiko, Ohkawa, Yasuyuki, Tashiro, Satoshi, Kimura, Hiroshi, Ikura, Tsuyoshi, Kurumizaka, Hitoshi
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2018
Предметы:
Gene regulation, Chromatin and Epigenetics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212774/
https://ncbi.nlm.nih.gov/pubmed/30053102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky661
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