Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome

Mutations of the Glu76 residue of canonical histone H2B are frequently found in cancer cells. However, it is quite mysterious how a single amino acid substitution in one of the multiple H2B genes affects cell fate. Here we found that the H2B E76K mutation, in which Glu76 is replaced by Lys (E76K), d...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Principais autores: Arimura, Yasuhiro, Ikura, Masae, Fujita, Risa, Noda, Mamiko, Kobayashi, Wataru, Horikoshi, Naoki, Sun, Jiying, Shi, Lin, Kusakabe, Masayuki, Harata, Masahiko, Ohkawa, Yasuyuki, Tashiro, Satoshi, Kimura, Hiroshi, Ikura, Tsuyoshi, Kurumizaka, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212774/
https://ncbi.nlm.nih.gov/pubmed/30053102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky661
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