Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks

The DNA damage checkpoint pathway is activated in response to DNA lesions and replication stress to preserve genome integrity. However, hyper-activation of this surveillance system is detrimental to the cell, because it might prevent cell cycle re-start after repair, which may also lead to senescenc...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Dibitetto, Diego, Ferrari, Matteo, Rawal, Chetan C., Balint, Attila, Kim, TaeHyung, Zhang, Zhaolei, Smolka, Marcus B., Brown, Grant W., Marini, Federica, Pellicioli, Achille
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737138/
https://ncbi.nlm.nih.gov/pubmed/26490958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1080
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