Functional Interplay between the 53BP1-Ortholog Rad9 and the Mre11 Complex Regulates Resection, End-Tethering and Repair of a Double-Strand Break

The Mre11-Rad50-Xrs2 nuclease complex, together with Sae2, initiates the 5′-to-3′ resection of Double-Strand DNA Breaks (DSBs). Extended 3′ single stranded DNA filaments can be exposed from a DSB through the redundant activities of the Exo1 nuclease and the Dna2 nuclease with the Sgs1 helicase. In t...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Ferrari, Matteo, Dibitetto, Diego, De Gregorio, Giuseppe, Eapen, Vinay V., Rawal, Chetan C., Lazzaro, Federico, Tsabar, Michael, Marini, Federica, Haber, James E., Pellicioli, Achille
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287487/
https://ncbi.nlm.nih.gov/pubmed/25569305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004928
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados