Copper‐Catalyzed Double Additions and Radical Cyclization Cascades in the Re‐Engineering of the Antibacterial Pleuromutilin

A general synthetic sequence involving simply prepared starting materials provides rapid access to diverse, novel tricyclic architectures inspired by pleuromutilin. Sm(II)‐mediated radical cyclization cascades of dialdehydes, prepared using a new, one‐pot, copper‐catalyzed double organomagnesium add...

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Bibliografske podrobnosti
izdano v:Chemistry
Main Authors: Ruscoe, Rebecca E., Fazakerley, Neal J., Huang, Huanming, Flitsch, Sabine, Procter, David J.
Format: Artigo
Jezik:Inglês
Izdano: WILEY‐VCH Verlag 2015
Teme:
Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4736435/
https://ncbi.nlm.nih.gov/pubmed/26527052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201504343
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