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Rhodium(iii)-catalyzed synthesis of phthalides by cascade addition and cyclization of benzimidates with aldehydes

We herein report the Rh(iii)-catalyzed C–H bond activation and addition of benzimidates to aldehydes to afford biologically important phthalides in a single step. The imidate is a novel and unexplored directing group that not only enables C–H bond activation and addition to aldehydes, but also serve...

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Autors principals: Lian, Yajing, Bergman, Robert G., Ellman, Jonathan A.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462028/
https://ncbi.nlm.nih.gov/pubmed/23050074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C2SC20835K
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