High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis

Hepatotoxicity is one of the most cited reasons for withdrawal of approved drugs from the market. The use of nonclinically relevant in vitro and in vivo testing systems contributes to the high attrition rates. Recent advances in differentiating human induced pluripotent stem cells (hiPSCs) into pure...

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Sparad:
Bibliografiska uppgifter
I publikationen:Stem Cells Int
Huvudupphovsmän: Pradip, Arvind, Steel, Daniella, Jacobsson, Susanna, Holmgren, Gustav, Ingelman-Sundberg, Magnus, Sartipy, Peter, Björquist, Petter, Johansson, Inger, Edsbagge, Josefina
Materialtyp: Artigo
Språk:Inglês
Publicerad: Hindawi Publishing Corporation 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4736406/
https://ncbi.nlm.nih.gov/pubmed/26880940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/2475631
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