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Hepatic Differentiation and Maturation of Human Embryonic Stem Cells Cultured in a Perfused Three-Dimensional Bioreactor

Drug-induced liver injury is a serious and frequently occurring adverse drug reaction in the clinics and is hard to predict during preclinical studies. Today, primary hepatocytes are the most frequently used cell model for drug discovery and prediction of toxicity. However, their use is marred by hi...

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Bibliografiske detaljer
Main Authors: Sivertsson, Louise, Synnergren, Jane, Jensen, Janne, Björquist, Petter, Ingelman-Sundberg, Magnus
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564470/
https://ncbi.nlm.nih.gov/pubmed/22970843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2012.0202
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