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Hepatic Differentiation and Maturation of Human Embryonic Stem Cells Cultured in a Perfused Three-Dimensional Bioreactor

Drug-induced liver injury is a serious and frequently occurring adverse drug reaction in the clinics and is hard to predict during preclinical studies. Today, primary hepatocytes are the most frequently used cell model for drug discovery and prediction of toxicity. However, their use is marred by hi...

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Hlavní autoři: Sivertsson, Louise, Synnergren, Jane, Jensen, Janne, Björquist, Petter, Ingelman-Sundberg, Magnus
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564470/
https://ncbi.nlm.nih.gov/pubmed/22970843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2012.0202
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