Metabolite Profiling and Pharmacokinetic Evaluation of Hydrocortisone in a Perfused Three-Dimensional Human Liver Bioreactor

Endotoxin lipopolysaccharide (LPS) is known to cause liver injury primarily involving inflammatory cells such as Kupffer cells, but few in vitro culture models are applicable for investigation of inflammatory effects on drug metabolism. We have developed a three-dimensional human microphysiological...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Drug Metab Dispos
Κύριοι συγγραφείς: Sarkar, Ujjal, Rivera-Burgos, Dinelia, Large, Emma M., Hughes, David J., Ravindra, Kodihalli C., Dyer, Rachel L., Ebrahimkhani, Mohammad R., Wishnok, John S., Griffith, Linda G., Tannenbaum, Steven R.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The American Society for Pharmacology and Experimental Therapeutics 2015
Θέματα:
Articles
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468434/
https://ncbi.nlm.nih.gov/pubmed/25926431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.063495
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