Metabolite Profiling and Pharmacokinetic Evaluation of Hydrocortisone in a Perfused Three-Dimensional Human Liver Bioreactor

Endotoxin lipopolysaccharide (LPS) is known to cause liver injury primarily involving inflammatory cells such as Kupffer cells, but few in vitro culture models are applicable for investigation of inflammatory effects on drug metabolism. We have developed a three-dimensional human microphysiological...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Sarkar, Ujjal, Rivera-Burgos, Dinelia, Large, Emma M., Hughes, David J., Ravindra, Kodihalli C., Dyer, Rachel L., Ebrahimkhani, Mohammad R., Wishnok, John S., Griffith, Linda G., Tannenbaum, Steven R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468434/
https://ncbi.nlm.nih.gov/pubmed/25926431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.063495
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados