Metabolite Profiling and Pharmacokinetic Evaluation of Hydrocortisone in a Perfused Three-Dimensional Human Liver Bioreactor

Endotoxin lipopolysaccharide (LPS) is known to cause liver injury primarily involving inflammatory cells such as Kupffer cells, but few in vitro culture models are applicable for investigation of inflammatory effects on drug metabolism. We have developed a three-dimensional human microphysiological...

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Udgivet i:Drug Metab Dispos
Main Authors: Sarkar, Ujjal, Rivera-Burgos, Dinelia, Large, Emma M., Hughes, David J., Ravindra, Kodihalli C., Dyer, Rachel L., Ebrahimkhani, Mohammad R., Wishnok, John S., Griffith, Linda G., Tannenbaum, Steven R.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468434/
https://ncbi.nlm.nih.gov/pubmed/25926431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.063495
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