Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System

In vitro hepatocyte culture systems have inherent limitations in capturing known human drug toxicities that arise from complex immune responses. Therefore, we established and characterized a liver immunocompetent coculture model and evaluated diclofenac (DCF) metabolic profiles, in vitro–in vivo cle...

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Pubblicato in:Drug Metab Dispos
Autori principali: Sarkar, Ujjal, Ravindra, Kodihalli C., Large, Emma, Young, Carissa L., Rivera-Burgos, Dinelia, Yu, Jiajie, Cirit, Murat, Hughes, David J., Wishnok, John S., Lauffenburger, Douglas A., Griffith, Linda G., Tannenbaum, Steven R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2017
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469400/
https://ncbi.nlm.nih.gov/pubmed/28450578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.074005
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