Chemoproteomics of matrix metalloproteases in a model of cartilage degeneration suggests functional biomarkers associated with posttraumatic osteoarthritis

Active matrix metalloproteases (MMPs) play a significant role in the pathogenesis of many diseases including osteoarthritis (OA), which involves progressive proteolytic degradation of cartilage. Clinical success of OA interventions that target MMPs has been limited by a lack of information about the...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Ravindra, Kodihalli C., Ahrens, Caroline C., Wang, Yang, Ramseier, Julie Y., Wishnok, John S., Griffith, Linda G., Grodzinsky, Alan J., Tannenbaum, Steven R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Genomics and Proteomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065175/
https://ncbi.nlm.nih.gov/pubmed/29794029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.818542
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