High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis

Hepatotoxicity is one of the most cited reasons for withdrawal of approved drugs from the market. The use of nonclinically relevant in vitro and in vivo testing systems contributes to the high attrition rates. Recent advances in differentiating human induced pluripotent stem cells (hiPSCs) into pure...

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Detalhes bibliográficos
Publicado no:Stem Cells Int
Main Authors: Pradip, Arvind, Steel, Daniella, Jacobsson, Susanna, Holmgren, Gustav, Ingelman-Sundberg, Magnus, Sartipy, Peter, Björquist, Petter, Johansson, Inger, Edsbagge, Josefina
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4736406/
https://ncbi.nlm.nih.gov/pubmed/26880940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/2475631
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