Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion

The precancerous lesion known as Barrett's oesophagus can evolve to oesophageal adenocarcinoma in decades-long processes of regenerative growth. Here we report the isolation and propagation of distinct, patient-matched stem cells of Barrett's, gastric and oesophageal epithelia that yield d...

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Vydáno v:Nat Commun
Hlavní autoři: Yamamoto, Yusuke, Wang, Xia, Bertrand, Denis, Kern, Florian, Zhang, Ting, Duleba, Marcin, Srivastava, Supriya, Khor, Chiea Chuen, Hu, Yuanyu, Wilson, Lane H., Blaszyk, Hagen, Rolshud, Daniil, Teh, Ming, Liu, Jianjun, Howitt, Brooke E., Vincent, Matthew, Crum, Christopher P., Nagarajan, Niranjan, Ho, Khek Yu, McKeon, Frank, Xian, Wa
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735693/
https://ncbi.nlm.nih.gov/pubmed/26783136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10380
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