Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion

The precancerous lesion known as Barrett's oesophagus can evolve to oesophageal adenocarcinoma in decades-long processes of regenerative growth. Here we report the isolation and propagation of distinct, patient-matched stem cells of Barrett's, gastric and oesophageal epithelia that yield d...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Yamamoto, Yusuke, Wang, Xia, Bertrand, Denis, Kern, Florian, Zhang, Ting, Duleba, Marcin, Srivastava, Supriya, Khor, Chiea Chuen, Hu, Yuanyu, Wilson, Lane H., Blaszyk, Hagen, Rolshud, Daniil, Teh, Ming, Liu, Jianjun, Howitt, Brooke E., Vincent, Matthew, Crum, Christopher P., Nagarajan, Niranjan, Ho, Khek Yu, McKeon, Frank, Xian, Wa
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735693/
https://ncbi.nlm.nih.gov/pubmed/26783136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10380
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